As the use of kinase inhibitors is gradually declining transcription factor inhibition is the next hot topic for oncology research and merits much attention this book highlights recent progress in the development of small molecule inhibitors of oncogenic transcription factors. This chapter covers the synthesis and the synthetic challenges associated with representative examples of each of the following classes of transcription factor inhibitors cyclin dependent kinase synthesis of flavopiridol stat3 phosphonodifluoromethyl isosteric analogue of a peptidomimetic including its pivaloyloxymethyl pro drug stat5b stafib 1 c myc max substituted benzanilide . Small molecule transcription factor inhibitors in oncology contents george procopiou and panayiotis a procopiou introduction 1 cyclin dependent kinase inhibitors flavopiridol 2 inhibitors of stat3 and stat5 7 inhibitors of c myc 11 inhibitors of hif 1 16 inhibitors of nf b and nf y 21 tandem deprotection cyclisation strategy to produce . Since their discovery in streptomyces bacteria over half a century ago pyrrolobenzodiazepines pbds have generated significant interest as potential chemotherapeutic agents due to their sequence selective dna alkylating capacity the development of synthetic pbd compounds from their naturally derived bacterial counterparts has enhanced both the potency and safety profiles of pbds. This book highlights recent progress in the development of small molecule inhibitors of oncogenic transcription factors and is relevant for postgraduates researchers and practitioners rating not yet rated 0 with reviews be the first
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