Introduction herpesviruses infections of humans are very common and prevalent in the population all herpesviruses establish latency in different tissues and periodic reactivation can lead to transmission although the majority of infections with herpes simplex virus hsv and cytomegalovirus cmv are clinically mild or even asymptomatic primary infection in the fetal and perinatal . Medically serious complications of herpes simplex virus hsv infection are rare but constitute a significant burden given the high rates of hsv seropositivity in the population 58 many prophylactic and therapeutic vaccination ap proaches have been explored for the prevention or treatment of hsv infection thorough reviews have included a . The herpes simplex virus also known as hsv is an infection that causes herpes herpes can appear in various parts of the body most commonly on the genitals or mouth. We have focused primarily on the five human herpesviruses herpes simplex virus 1 hsv l herpes simplex virus 2 hsv 2 cytomegalovirus cmv varicella zoster virus vzv and epstein barr virus ebv because much more is known about them than about any other herpesviruses and because it is of interest to compare both the diversity of . Herpes simplex virus hsv is a highly prevalent infection globally with the most common type affecting around 37 billion people under the age of 50 years it spreads rapidly through direct
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